Список валидированных методик
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№      АналитМетодLLOQ (ng/mL)Примечание
1 11-Deoxycortisol HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
2 17-Carboxybudesonide HPLC/MS/MS 0,1 in dog plasma
3 17-Deacetylnorgestimate HPLC/MS/MS 0,02  
4 17-Hydroxyprogesterone HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
5 1-Adamantylethyloxy-3-morpholino-2-propanol HPLC/MS/MS 0,05  
6 2-Hydroxymethylmetronidazole HPLC/MS/MS 4  
7 1-Hydroxymidazolam HPLC/MC/MS 0,2  
8 2-Pyridylacetic acid HPLC/MS/MS 200  
9 4-Methylaminoantipyrine (MAA) HPLC/MS/MS 100  
10 5'-Deoxy-5-fluorocytidine HPLC/MS/MS 25  
11 5'-Deoxy-5-fluorouridine HPLC/MS/MS 25  
12 5-Fluorouracil HPLC/MS/MS 5  
13 5-Hydroxymethyltolterodine HPLC/MS/MS 0,05  
14 5-Hydroxypropafenone HPLC/MS/MS 0,5  
15 9-Hydroxyrisperidone HPLC/MS/MS 0,1  
16 Abiraterone HPLC/MS/MS 0,2  
17 Acetaminophen (paracetamol) HPLC/MS/MS 250  
18 Acetazolamide HPLC/MS/MS 250  
19 Acetylcysteine HPLC/MS/MS 50  
20 Acetylsalicylic acid HPLC/MS/MS 25 common method with salicylic acid
21 Acetylsalicylic acid HPLC/MS/MS 20  
22 Acetylsalicylic acid HPLC/MS/MS 5 common method with salicylic acid
23 Aciclovir HPLC 15  
24 Aciclovir HPLC/MS/MS 5  
25 Agomelatine HPLC/MS/MS 0,1  
26 Aldosterone HPLC/MS/MS 0,01 determination of endogenous levels in postmenopausal women
27 Alendronate HPLC/MS/MS 0,75  
28 Ambroxol HPLC/MS/MS 1  
29 Amlodipine HPLC/MS/MS 0,1  
30 Amlodipine HPLC/MS/MS 0,5 rat plasma direct injection
31 Amlodipine chiral HPLC/MS/MS 0,2  
32 Amoxicillin HPLC/MS/MS 100  
33 Amoxicillin HPLC/MS/MS 350 common method with Clavulanic acid
34 Amoxicillin HPLC/MS/MS 500 common method with Clavulanic acid
35 Anagrelide HPLC/MS/MS 0,075  
36 Anastrozole HPLC/MS/MS 0,5  
37 Androstenedione HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
38 Aripiprazene HPLC/MS/MS 0,1  
39 Aripiprazole HPLC/MS/MS 0,4  
40 Atomoxetine HPLC/MS/MS 5  
41

Atorvastatin

HPLC/MS/MS 0,8 common method with ezetimibe
42 Atorvastatin HPLC/MS/MS 0,5  
43 Atorvastatin HPLC/MS/MS 0,25 common method with Ezetimibe and Ezetimibe Glucuronide
44 Azithromycin HPLC/MS/MS 4  
45 Bendroflumethiazide HPLC/MS/MS 0,4  
46 Bicalutamide chiral HPLC/MS/MS 1  
47 Bicalutamide HPLC/MS/MS 2  
48 Bisoprolol HPLC/MS/MS 0,5  
49 Bosentan HPLC/MS/MS 5  
50 Bosentan HPLC/MS/MS 20  
51 Budesonide HPLC/MS/MS 0,05 in dog plasma
52 Bumetanide HPLC 4  
53 Caffeine HPLC/MS/MS 100 common method with paraxantine
54 Candesartan HPLC/MS/MS 2  
55 Capecitabine HPLC/MS/MS 100  
56 Captopril (free) HPLC/MS/MS 1  
57 Captopril (free) HPLC/MS/MS 10  
58 Captopril (free) HPLC 15  
59 Carbamazepine HPLC 25  
60 Carbocisteine HPLC/MS/MS 50  
61 Carvedilol HPLC/MS/MS 1  
62 Carvedilol metabolite M IV HPLC/MS/MS 0,2  
63 Cefditoren HPLC/MS/MS 50  
64 Cefixime HPLC/MS/MS 100  
65 Cefprozil HPLC/MS/MS 100  
66 Cefuroxime HPLC/MS/MS 50  
67 Celecoxib HPLC/MS/MS 10  
68 Chlorambucil HPLC/MS/MS 1  
69 Chlorthalidone HPLC/MS/MS 2  
70 Choline HPLC/MS/MS 30  
71 Cilostazol HPLC/MS/MS 50  
72 Ciprofloxacine HPLC/MS/MS 50  
73 Clarithromycin HPLC/MS/MS 50  
74 Clavulanic acid HPLC/MS/MS 80 Common method with Amoxicillin
75 Clavulanic acid HPLC/MS/MS 100 Common method with Amoxicillin
76 Clobazam HPLC/MS/MS 1  
77 Clozapin GC/MS 0,6  
78 C-peptide ELISA 0,2  
79 Cytisine HPLC/MS/MS 0,4  
80 Dabigatran HPLC/MS/MS 0,5  
81 Dapagliflozin HPLC/MS/MS 2 common method with linagliptin
82 Darunavir HPLC/MS/MS 200  
83 Dasatinib HPLC/MS/MS 0,05  
84 Dasatinib HPLC/MS/MS 0,25  
85 Desethyloxybutynin GC/MS 2  
86 Desethyloxybutynin HPLC 4  
87 Desloratadine HPLC/MS/MS 0,05  
88 Desmethylfluoxetine GC/MS 0,4  
89 Dexamethasone HPLC/MS/MS 0,25  
90 Diphenhydramine HPLC/MS/MS 1,0  
91 Doxylamine HPLC/MS/MS 2  
92 Dexketoprofen HPLC/MS/MS 50  
93 Dextromethorphan HPLC/MS/MS 0,01  
94 Diclofenac HPLC/MS/MS 5  
95 Didanosine HPLC/MS/MS 20  
96 Dienogest HPLC/MS/MS 1  
97 Diosmetin-3-O-glucuronide HPLC/MS/MS 0,05  
98 Domperidone HPLC/MS/MS 0,5  
99 Donepezil HPLC/MS/MS 0,2  
100 Donepezil HPLC/MS/MS 0,4 common method with memantine
101 Doxazosin HPLC/MS/MS 0,4  
102 Doxycycline HPLC/MS/MS 40,0  
103 Drospirenone HPLC/MS/MS 0,5  
104 Drotaverine HPLC/MS/MS 3  
105 Duloxetine HPLC/MS/MS 0,5  
106 Dutasteride HPLC/MS/MS 0,05  
107 Emoxipine HPLC/MS/MS 5  
108 Emtricitabine HPLC/MS/MS 5 (common with Tenofovir)
109 Emtricitabine HPLC/MS/MS 5  
110 Enalapril HPLC/MS/MS 1  
111 Enalaprilat HPLC/MS/MS 1,2  
112 Entecavir HPLC/MS/MS 0,05  
113 Epinephrine HPLC/MS/MS 0,01  
114 Eplerenon HPLC/MS/MS 10  
115 Epoxycarbamazepin HPLC 25  
116 Erlotinib HPLC/MS/MS 5  
117 Escitalopram HPLC/MS/MS 0,25  
118 Esomeprazole HPLC/MS/MS 10  
119 Estradiol HPLC/MS/MS 0,0008 determination of endogenous levels in postmenopausal women
120 Estrone HPLC/MS/MS 0,001 determination of endogenous levels in postmenopausal women
121 Estrone sulfate HPLC/MS/MS 0,01 determination of endogenous levels in postmenopausal women
122 Eszopiclon HPLC/MS/MS 0,25  
123 Ethinylestradiol HPLC/MS/MS 0,001  
124 Ethylmethylhydroxypyridine HPLC/MS/MS 0,25  
125 Ethylmethylhydroxypyridine HPLC/MS/MS 1  
126 Etoricoxib HPLC/MS/MS 5  
127 Everolimus HPLC/MS/MS 1 in whole blood
128 Exemestane HPLC/MS/MS 0,25  
129 Ezetimibe HPLC/MS/MS 0,04 common method with ezetimibe glucuronide
130 Ezetimibe HPLC/MS/MS 0,08 common method with atorvastatin
131 Ezetimibe HPLC/MS/MS 0,05 common method with simvastatin
132 Ezetimibe HPLC/MS/MS 0,05 common method with Atorvastatin and Ezetimibe Glucuronide
133 Ezetimibe glucuronide HPLC/MS/MS 1 common method with Atorvastatin and Ezetimibe
134 Ezetimibe glucuronide HPLC/MS/MS 0,8 common method with ezetimibe
135 Ezetimibe glucuronide HPLC/MS/MS 0,8 common method with atorvastatin
136 Famotidine HPLC/MS/MS 2,5  
137 Fampridine HPLC/MS/MS 0,5  
138 Fampridine HPLC/MS/MS 1  
139 Fenpiverinium HPLC/MS/MS 0,03 common method with ketorolac and pitofenone
140 Fenpiverinium HPLC/MS/MS 0,00025 common method with pitofenone
141 Fenspiride HPLC/MS/MS 1  
142 Fenspiride HPLC/MS/MS 1  
143 Fingolimod HPLC/MS/MS 0,01 in whole blood
144 Fluoxetine GC/MS 0,4  
145 Flupirtine HPLC/MS/MS 20  
146 Flupirtine HPLC/MS/MS 10  
147 Flurbiprofen HPLC/MS/MS 100  
148 Fluvoxamine HPLC 1,5  
149 Fosfomycin HPLC/MS/MS 500  
150 Fulvestrant HPLC/MS/MS 0,2  
151 Furagin (Furazidine) HPLC/MS/MS 2  
152 Furagin (Furazidine) HPLC/MS/MS 100  
153 Ganciclovir HPLC/MS/MS 50  
154 Gefitinib HPLC/MS/MS 2  
155 Gentamicin HPLC/MS/MS   in animals samples
156 Glargine ELISA 7,5 µU/mL  
157 Gliclazide HPLC/MS/MS 20  
158 Glimepiride HPLC/MS/MS 1  
159 Glucosamine HPLC/MS/MS 10  
160 Glycoursodeoxycholic acid HPLC/MS/MS 20 endogenous compound
161 Hydrochlorothiazide HPLC/MS/MS 0,2  
162 Hydrochlorothiazide HPLC/MS/MS 0,5  
163 Hydrocortisone HPLC/MS/MS 10 endogenous compound
164 Hydroxyurea HPLC/MS/MS 250  
165 Ibuprofen HPLC/MS/MS 500  
166 Ibuprofen HPLC/MS/MS 250  
167 Ibuprofen (S, R — isomers, enantioselective) HPLC/MS/MS 250  
168 Isoprinosine (DIP) HPLC/MS/MS 10  
169 Isoprinosine (PAcBA) HPLC/MS/MS 50  
170 Imatinib HPLC/MS/MS 20  
171 Indapamide HPLC/MS/MS 1 in whole blood
172 Indapamide HPLC/MS/MS 0,5 in whole blood
173 Insulin ELISA 6,25 µIU/mL  
174 Insulin ELISA 12,5 µIU/mL  
175 Insulin ELISA 4 µIU/mL  
176 Insulin aspart ELISA 10 µIU/mL  
177 Ipidacrine HPLC/MS/MS 0,1  
178 Irbesartan HPLC/MS/MS 5  
179 Isoprinosine (DIP) HPLC/MS/MS 80  
180 Isoprinosine (PAcBA) HPLC/MS/MS 200  
181 Itopride HPLC/MS/MS 10,0  
182 Ivabradine HPLC/MS/MS 0,25  
183 Ketorolac HPLC/MS/MS 3 common method with fenpiverinium and pitofenone
184 Ketorolac HPLC/MS/MS 30  
185 Lacidipine HPLC/MS/MS 0,02  
186 Ladostigil HPLC/MS/MS 0,2  
187 Lenalidomide HPLC/MS/MS 2  
188 Letrozole HPLC/MS/MS 0,5  
189 Letrozole HPLC/MS/MS 1  
190 Levetiracetam HPLC/MS/MS 200  
191 Levocetirizine HPLC/MS/MS 2,5  
192 Levocetirizine HPLC/MS/MS 1 common method with montelucast
193 Levofloxacine HPLC/MS/MS 100  
194 Levothyroxine HPLC/MS/MS 10 endogenous compound
195 Linagliptin HPLC/MS/MS 0,1 common method with dapagliflozin
196 Linezolid HPLC/MS/MS 200  
197 Liothyronine HPLC/MS/MS 0,25 endogenous compound
198 Lisinopril HPLC/MS/MS 1  
199 Lorazepam HPLC/MS/MS 0,4  
200 Lornoxicam HPLC/MS/MS 20  
201 Losartan HPLC/MS/MS 3  
202 Lovastatin GC/MS/MS 0,15  
203 Lovastatin hydroxyacid GC/MS/MS 0,15  
204 Mebeverine acid HPLC/MS/MS 10  
205 Mebeverine acid, desmethyl HPLC/MS/MS 10  
206 Megestrol acetate HPLC/MS/MS 1  
207 Melatonin HPLC/MS/MS 0,01  
208 Meldonium HPLC/MS/MS 100  
209 Meloxicam HPLC/MS/MS 0,05  
210 Meloxicam HPLC/MS/MS 30  
211 Meloxicam HPLC/MS/MS 20  
212 Memantine HPLC/MS/MS 0,1  
213 Memantine HPLC/MS/MS 0,2  
214 Memantine HPLC/MS/MS 0,5 common method with donepezile
215 Metformin HPLC/MS/MS 10  
216 Methyldopa HPLC/MS/MS 20  
217 Methylsulfoxyethanol (MSE) HPLC/MS/MS 200  
218 Metoprolol HPLC/MS/MS 1  
219 Metronidazole HPLC/MS/MS 20  
220 Mianserin chiral HPLC/MS/MS 0,2  
221 Micophenolic acid HPLC/MS/MS 500  
222 Midazolam HPLC/MS/MS 0,2  
223 Mildronate HPLC/MS/MS 50  
224 Milnacipran HPLC/MS/MS 2  
225 Misoprostol acid HPLC/MS/MS 0,005  
226 Misoprostol acid HPLC/MS/MS 0,05  
227 Misoprostol acid HPLC/MS/MS 0,025  
228 Moclobemide HPLC 30  
229 Montelukast HPLC/MS/MS 1  
230 Montelukast HPLC/MS/MS 2 common method with levocetirizine
231 Moxifloxacin HPLC/MS/MS 50  
232 Moxonidine HPLC/MS/MS 0,02  
233 N,N-Didesmethil Sibutramine HPLC/MS/MS 0,1 common method with N-Desmethil Sibutramine and Sibutramine
234 N-Desmethil Sibutramine HPLC/MS/MS 0,1 common method with N-Didesmethyl Sibutramine and Sibutramine
235 N-Desmethil Trimebutine HPLC/MS/MS 30,0  
236 Naftidrofuryl HPLC 200  
237 Naproxen HPLC/MS/MS 200  
238 Naproxen HPLC/MS/MS 10 in urine
239 Naproxen HPLC/MS/MS 500  
240 Nebivolol HPLC/MS/MS 0,02  
241 Nerofe HPLC/MS/MS 1 000,00 in dog plasma
242 Nevirapine HPLC/MS/MS 25  
243 Nitrofurantoin HPLC/MS/MS 2  
244 Norgestimate HPLC/MS/MS 0,0004  
245 O-desmethyltramadol HPLC/MS/MS 0,5  
246 O-desmethylvenlafaxine HPLC/MS/MS 0,5  
247 O-hydroxy atorvastatin HPLC/MS/MS 0,4 common method with ezetimibe
248 Olanzapine HPLC/MS/MS 0,1  
249 Olanzapine HPLC/MS/MS 0,25  
250 Olmesartan HPLC/MS/MS 10  
251 Omeprazole HPLC/MS/MS 10  
252 Ondansetron HPLC/MS/MS 1  
253 Oracin HPLC 20  
254 Ornidazole HPLC/MS/MS 200  
255 Oseltamivir HPLC/MS/MS 0,5  
256 Oxybutynin GC/MS 0,2  
257 Paliperidon HPLC/MS/MS 0,2  
258 Paraxantine HPLC/MS/MS 100 common method with caffeine
259 Paroxetine HPLC/MS/MS 0,1  
260 Paroxetine HPLC/MS/MS 0,025  
261 Paroxetine metabolite HPLC/MS/MS 0,2  
262 Pazopanib HPLC/MS/MS 100  
263 Pentoxifylline HPLC/MS/MS 1  
264 Pentoxifylline metabolite M1 HPLC/MS/MS 2  
265 Pentoxifylline metabolite M5 HPLC/MS/MS 10  
266 Perindopril HPLC/MS/MS 2,0  
267 Perindopril HPLC/MS/MS 2,5 common method with perindoprilate
268 Perindoprilate HPLC/MS/MS 0,25 commo method with perindopril
269 p-hydroxy atorvastatin HPLC/MS/MS 0,04 common method with ezetimibe
270 Pioglitazone HPLC/MS/MS 10  
271 Pioglitazone metabolite M IV HPLC/MS/MS 5  
272 Piracetam HPLC/MS/MS 500  
273 Pitofenone HPLC/MS/MS 1 common method with ketorolac and fenpiverinium
274 Pitofenone HPLC/MS/MS 0,002 commo method with fenpiverinium
275 Pizotifen GC/MS/MS 0,05  
276 Pramipexole HPLC/MS/MS 0,02  
277 Pramipexole HPLC/MS/MS 0,01  
278 Prednisolone HPLC/MS/MS 3  
279 Pregabalin HPLC/MS/MS 50  
280 Pridinol HPLC/MS/MS 0,2  
281 Pridinol HPLC/MS/MS 1 in urine
282 Propafenone HPLC/MS/MS 1  
283 Propiverine HPLC/MS/MS 0,5  
284 Quetiapine HPLC/MS/MS 1  
285 Quifenadine HPLC/MS/MS 0,2  
286 Raloxifene HPLC/MS/MS 0,01  
287 Raloxifene-4-glucoronide HPLC/MS/MS 1  
288 Raloxifene-6-glucoronide HPLC/MS/MS 0,5  
289 Ramipril HPLC/MS/MS 0,2  
290 Ramipril HPLC/MS/MS 0,4  
291 Ramipril HPLC/MS/MS 0,05 in dog plasma
292 Ramiprilate HPLC/MS/MS 0,2  
293 Ramiprilate HPLC/MS/MS 0,5 in dog plasma
294 Ranitidin HPLC 10  
295 Ranolazine HPLC/MS/MS 25  
296 Rasagiline HPLC/MS/MS 0,1  
297 Rebamipide HPLC/MS/MS 4  
298 Ribavirin HPLC/MS/MS 3  
299 Risperidone HPLC/MS/MS 0,1  
300 Ritonavir HPLC/MS/MS 20  
301 Rizatriptan HPLC/MS/MS 0,1  
302 Ropinirole HPLC/MS/MS 0,1  
303 Rosuvastatin HPLC/MS/MS 0,05  
304 Salicylic acid HPLC 200  
305 Salicylic acid HPLC/MS/MS 100 common method with acetylsalicylic acid
306 Salicylic acid HPLC/MS/MS 20 common method with acetylsalicylic acid
307 Sibutramine HPLC/MS/MS 0,1 common method with NN-Didesmethyl Sibutramine and N-desmethil Sibutramine
308 Sildenafil HPLC/MS/MS 1  
309 Sildenafil HPLC/MS/MS 5  
310 Simvastatin GC/MS/MS 0,5  
311 Simvastatin LC/MS/MS 0,5  
312 Simvastatin LC/MS/MS 0,2 common method with ezetimibe
313 Simvastatin LC/MS/MS 0,2  
314 Simvastatin hydroxyacid GC/MS/MS 0,1  
315 Simvastatin hydroxyacid LC/MS/MS 0,1  
316 Simvastatin hydroxyacid LC/MS/MS 0,05 common method with ezetimibe
317 Sitagliptin HPLC/MS/MS 1  
318 Solifenacin HPLC/MS/MS 0,2  
319 Sunitinibe HPLC/MS/MS 0,1  
320 Tadalafil HPLC/MS/MS 5  
321 Tamsulosin HPLC/MS/MS 0,2  
322 Tamsulosin HPLC/MS/MS 0,1  
323 Tamsulosin HPLC/MS/MS 0,05  
324 Tauroursodeoxycholic acid HPLC/MS/MS 5 endogenous compound
325 Telmisartan HPLC/MS/MS 2  
326 Tenofovir HPLC/MS/MS 5  
327 Tenofovir HPLC/MS/MS 5 common method with emtricitabine
328 Terbinafine HPLC/MS/MS 20  
329 Teriflunomide HPLC/MS/MS 100  
330 Thiocolchicoside metabolite M1 HPLC/MS/MS 1  
331 Thiocolchicoside HPLC/MS/MS 0,01  
332 Tianeptine chiral HPLC/MS/MS 2  
333 Tilorone HPLC/MS/MS 0,75  
334 Ticagrelor HPLC/MS/MS 5  
335 Tiotropium HPLC/MS/MS 0,0001  
336

Atorvastatin

HPLC/MS/MS 0,8 common method with ezetimibe
337 Tolperisone HPLC/MS/MS 0,5  
338 Tolterodine HPLC/MS/MS 0,05  
339 Torasemide HPLC/MS/MS 20  
340 Toremifene HPLC/MS/MS 2  
341 Tramadol GC/MS 6  
342 Tramadol HPLC/MS/MS 5  
343 Trimetazidine HPLC/MS/MS 0,5  
344 Ulipristal HPLC/MS/MS 0,2  
345 Uridine HPLC/MS/MS 150 endogenous compound
346 Uridine HPLC/MS/MS 30,0  
347 Ursodeoxycholic acid HPLC/MS/MS 10 endogenous compound
348 Ursodeoxycholic acid HPLC/MS/MS 40,0 common method with tauroursodeoxycholic acid and glycodeoxycholic acid
349 Valganciclovir HPLC/MS/MS 5  
350 Valproic acid HPLC/MS/MS 250  
351 Valsartan HPLC/MS/MS 50  
352 Vardenafil HPLC/MS/MS 0,25  
353 Venlafaxine HPLC/MS/MS 10 in rat plasma
354 Venlafaxine HPLC/MS/MS 0,5  
355 Vildagliptin HPLC/MS/MS 2  
356 Vinpocetine HPLC/MS/MS 0,3  
357 Voriconazole HPLC/MS/MS 5  
358 Warfarin HPLC 20  
359 Zidovudine HPLC/MS/MS 25  
360 Zolpidem HPLC 1 plasma direct injection
361 Zopiclon HPLC 4  
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