Список валидированных методик
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№       АналитМетодLLOQ (ng/mL)Примечание
1 11-Deoxycortisol HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
2 17-Carboxybudesonide HPLC/MS/MS 0,1 in dog plasma
3 17-Deacetylnorgestimate HPLC/MS/MS 0,02  
4 17-Hydroxyprogesterone HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
5 1-Adamantylethyloxy-3-morpholino-2-propanol HPLC/MS/MS 0,05  
6 2-Hydroxymethylmetronidazole HPLC/MS/MS 4  
7 1-Hydroxymidazolam HPLC/MC/MS 0,2  
8 2-Pyridylacetic acid HPLC/MS/MS 200  
9 4-Methylaminoantipyrine (MAA) HPLC/MS/MS 100  
10 5'-Deoxy-5-fluorocytidine HPLC/MS/MS 25  
11 5'-Deoxy-5-fluorouridine HPLC/MS/MS 25  
12 5-Fluorouracil HPLC/MS/MS 5  
13 5-Hydroxymethyltolterodine HPLC/MS/MS 0,05  
14 5-Hydroxypropafenone HPLC/MS/MS 0,5  
15 9-Hydroxyrisperidone HPLC/MS/MS 0,1  
16 Abiraterone HPLC/MS/MS 0,2  
17 Acetaminophen (paracetamol) HPLC/MS/MS 250  
18 Acetazolamide HPLC/MS/MS 250  
19 Acetylcysteine HPLC/MS/MS 50  
20 Acetylsalicylic acid HPLC/MS/MS 25 common method with salicylic acid
21 Acetylsalicylic acid HPLC/MS/MS 20  
22 Acetylsalicylic acid HPLC/MS/MS 5 common method with salicylic acid
23 Aciclovir HPLC 15  
24 Aciclovir HPLC/MS/MS 5  
25 Agomelatine HPLC/MS/MS 0,1  
26 Aldosterone HPLC/MS/MS 0,01 determination of endogenous levels in postmenopausal women
27 Alendronate HPLC/MS/MS 0,75  
28 Ambroxol HPLC/MS/MS 1  
29 Amlodipine HPLC/MS/MS 0,1  
30 Amlodipine HPLC/MS/MS 0,5 rat plasma direct injection
31 Amlodipine chiral HPLC/MS/MS 0,2  
32 Amoxicillin HPLC/MS/MS 100  
33 Amoxicillin HPLC/MS/MS 350 common method with Clavulanic acid
34 Amoxicillin HPLC/MS/MS 500 common method with Clavulanic acid
35 Anagrelide HPLC/MS/MS 0,075  
36 Anastrozole HPLC/MS/MS 0,5  
37 Androstenedione HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
38 Aripiprazene HPLC/MS/MS 0,1  
39 Aripiprazole HPLC/MS/MS 0,4  
40 Atomoxetine HPLC/MS/MS 5  
41

Atorvastatin

HPLC/MS/MS 0,8 common method with ezetimibe
42 Atorvastatin HPLC/MS/MS 0,5  
43 Atorvastatin HPLC/MS/MS 0,25 common method with Ezetimibe and Ezetimibe Glucuronide
44 Azithromycin HPLC/MS/MS 4  
45 Bendroflumethiazide HPLC/MS/MS 0,4  
46 Bicalutamide chiral HPLC/MS/MS 1  
47 Bicalutamide HPLC/MS/MS 2  
48 Bisoprolol HPLC/MS/MS 0,5  
49 Bosentan HPLC/MS/MS 5  
50 Bosentan HPLC/MS/MS 20  
51 Budesonide HPLC/MS/MS 0,05 in dog plasma
52 Bumetanide HPLC 4  
53 Caffeine HPLC/MS/MS 100 common method with paraxantine
54 Candesartan HPLC/MS/MS 2  
55 Capecitabine HPLC/MS/MS 100  
56 Captopril (free) HPLC/MS/MS 1  
57 Captopril (free) HPLC/MS/MS 10  
58 Captopril (free) HPLC 15  
59 Carbamazepine HPLC 25  
60 Carbocisteine HPLC/MS/MS 50  
61 Carvedilol HPLC/MS/MS 1  
62 Carvedilol metabolite M IV HPLC/MS/MS 0,2  
63 Cefditoren HPLC/MS/MS 50  
64 Cefixime HPLC/MS/MS 100  
65 Cefprozil HPLC/MS/MS 100  
66 Cefuroxime HPLC/MS/MS 50  
67 Celecoxib HPLC/MS/MS 10  
68 Chlorambucil HPLC/MS/MS 1  
69 Chlorthalidone HPLC/MS/MS 2  
70 Choline HPLC/MS/MS 30  
71 Cilostazol HPLC/MS/MS 50  
72 Ciprofloxacine HPLC/MS/MS 50  
73 Clarithromycin HPLC/MS/MS 50  
74 Clavulanic acid HPLC/MS/MS 80 Common method with Amoxicillin
75 Clavulanic acid HPLC/MS/MS 100 Common method with Amoxicillin
76 Clobazam HPLC/MS/MS 1  
77 Clozapin GC/MS 0,6  
78 C-peptide ELISA 0,2  
79 Cytisine HPLC/MS/MS 0,4  
80 Dabigatran HPLC/MS/MS 0,5  
81 Dapagliflozin HPLC/MS/MS 2 common method with linagliptin
82 Darunavir HPLC/MS/MS 200  
83 Dasatinib HPLC/MS/MS 0,05  
84 Dasatinib HPLC/MS/MS 0,25  
85 Desethyloxybutynin GC/MS 2  
86 Desethyloxybutynin HPLC 4  
87 Desloratadine HPLC/MS/MS 0,05  
88 Desmethylfluoxetine GC/MS 0,4  
89 Dexamethasone HPLC/MS/MS 0,25  
90 Diphenhydramine HPLC/MS/MS 1,0  
91 Doxylamine HPLC/MS/MS 2  
92 Dexketoprofen HPLC/MS/MS 50  
93 Dextromethorphan HPLC/MS/MS 0,01  
94 Diclofenac HPLC/MS/MS 5  
95 Didanosine HPLC/MS/MS 20  
96 Dienogest HPLC/MS/MS 1  
97 Diosmetin-3-O-glucuronide HPLC/MS/MS 0,05  
98 Domperidone HPLC/MS/MS 0,5  
99 Donepezil HPLC/MS/MS 0,2  
100 Donepezil HPLC/MS/MS 0,4 common method with memantine
101 Doxazosin HPLC/MS/MS 0,4  
102 Doxycycline HPLC/MS/MS 40,0  
103 Drospirenone HPLC/MS/MS 0,5  
104 Drotaverine HPLC/MS/MS 3  
105 Duloxetine HPLC/MS/MS 0,5  
106 Dutasteride HPLC/MS/MS 0,05  
107 Emoxipine HPLC/MS/MS 5  
108 Emtricitabine HPLC/MS/MS 5 (common with Tenofovir)
109 Emtricitabine HPLC/MS/MS 5  
110 Enalapril HPLC/MS/MS 1  
111 Enalaprilat HPLC/MS/MS 1,2  
112 Entecavir HPLC/MS/MS 0,05  
113 Epinephrine HPLC/MS/MS 0,01  
114 Eplerenon HPLC/MS/MS 10  
115 Epoxycarbamazepin HPLC 25  
116 Erlotinib HPLC/MS/MS 5  
117 Escitalopram HPLC/MS/MS 0,25  
118 Esomeprazole HPLC/MS/MS 10  
119 Estradiol HPLC/MS/MS 0,0008 determination of endogenous levels in postmenopausal women
120 Estrone HPLC/MS/MS 0,001 determination of endogenous levels in postmenopausal women
121 Estrone sulfate HPLC/MS/MS 0,01 determination of endogenous levels in postmenopausal women
122 Eszopiclon HPLC/MS/MS 0,25  
123 Ethinylestradiol HPLC/MS/MS 0,001  
124 Ethosuximide HPLC/MS/MS 100  
125 Ethylmethylhydroxypyridine HPLC/MS/MS 0,25  
126 Ethylmethylhydroxypyridine HPLC/MS/MS 1  
127 Etoricoxib HPLC/MS/MS 5  
128 Everolimus HPLC/MS/MS 1 in whole blood
129 Exemestane HPLC/MS/MS 0,25  
130 Ezetimibe HPLC/MS/MS 0,04 common method with ezetimibe glucuronide
131 Ezetimibe HPLC/MS/MS 0,08 common method with atorvastatin
132 Ezetimibe HPLC/MS/MS 0,05 common method with simvastatin
133 Ezetimibe HPLC/MS/MS 0,05 common method with Atorvastatin and Ezetimibe Glucuronide
134 Ezetimibe glucuronide HPLC/MS/MS 1 common method with Atorvastatin and Ezetimibe
135 Ezetimibe glucuronide HPLC/MS/MS 0,8 common method with ezetimibe
136 Ezetimibe glucuronide HPLC/MS/MS 0,8 common method with atorvastatin
137 Famotidine HPLC/MS/MS 2,5  
138 Fampridine HPLC/MS/MS 0,5  
139 Fampridine HPLC/MS/MS 1  
140 Fenpiverinium HPLC/MS/MS 0,03 common method with ketorolac and pitofenone
141 Fenpiverinium HPLC/MS/MS 0,00025 common method with pitofenone
142 Fenspiride HPLC/MS/MS 1  
143 Fenspiride HPLC/MS/MS 1  
144 Fingolimod HPLC/MS/MS 0,01 in whole blood
145 Fluoxetine GC/MS 0,4  
146 Flupirtine HPLC/MS/MS 20  
147 Flupirtine HPLC/MS/MS 10  
148 Flurbiprofen HPLC/MS/MS 100  
149 Fluvoxamine HPLC 1,5  
150 Fosfomycin HPLC/MS/MS 500  
151 Fulvestrant HPLC/MS/MS 0,2  
152 Furagin (Furazidine) HPLC/MS/MS 2  
153 Furagin (Furazidine) HPLC/MS/MS 100  
154 Gabapentin HPLC/MS/MS 100  
155 Ganciclovir HPLC/MS/MS 50  
156 Gefitinib HPLC/MS/MS 2  
157 Gentamicin HPLC/MS/MS   in animals samples
158 Glargine ELISA 7,5 µU/mL  
159 Gliclazide HPLC/MS/MS 20  
160 Glimepiride HPLC/MS/MS 1  
161 Glucosamine HPLC/MS/MS 10  
162 Glycoursodeoxycholic acid HPLC/MS/MS 20 endogenous compound
163 Hydrochlorothiazide HPLC/MS/MS 0,2  
164 Hydrochlorothiazide HPLC/MS/MS 0,5  
165 Hydrocortisone HPLC/MS/MS 10 endogenous compound
166 Hydroxyurea HPLC/MS/MS 250  
167 Ibuprofen HPLC/MS/MS 500  
168 Ibuprofen HPLC/MS/MS 250  
169 Ibuprofen (S, R — isomers, enantioselective) HPLC/MS/MS 250  
170 Isoprinosine (DIP) HPLC/MS/MS 10  
171 Isoprinosine (PAcBA) HPLC/MS/MS 50  
172 Imatinib HPLC/MS/MS 20  
173 Indapamide HPLC/MS/MS 1 in whole blood
174 Indapamide HPLC/MS/MS 0,5 in whole blood
175 Insulin ELISA 6,25 µIU/mL  
176 Insulin ELISA 12,5 µIU/mL  
177 Insulin ELISA 4 µIU/mL  
178 Insulin aspart ELISA 10 µIU/mL  
179 Ipidacrine HPLC/MS/MS 0,1  
180 Irbesartan HPLC/MS/MS 5  
181 Isoprinosine (DIP) HPLC/MS/MS 80  
182 Isoprinosine (PAcBA) HPLC/MS/MS 200  
183 Itopride HPLC/MS/MS 10,0  
184 Ivabradine HPLC/MS/MS 0,25  
185 Ketorolac HPLC/MS/MS 3 common method with fenpiverinium and pitofenone
186 Ketorolac HPLC/MS/MS 30  
187 Lacidipine HPLC/MS/MS 0,02  
188 Ladostigil HPLC/MS/MS 0,2  
189 Lenalidomide HPLC/MS/MS 2  
190 Letrozole HPLC/MS/MS 0,5  
191 Letrozole HPLC/MS/MS 1  
191 Levetiracetam HPLC/MS/MS 200  
192 Levocetirizine HPLC/MS/MS 2,5  
193 Levocetirizine HPLC/MS/MS 1 common method with montelucast
194 Levofloxacine HPLC/MS/MS 100  
195 Levothyroxine HPLC/MS/MS 10 endogenous compound
196 Linagliptin HPLC/MS/MS 0,1 common method with dapagliflozin
197 Linezolid HPLC/MS/MS 200  
198 Liothyronine HPLC/MS/MS 0,25 endogenous compound
199 Lisinopril HPLC/MS/MS 1  
200 Lorazepam HPLC/MS/MS 0,4  
201 Lornoxicam HPLC/MS/MS 20  
202 Losartan HPLC/MS/MS 3  
203 Lovastatin GC/MS/MS 0,15  
204 Lovastatin hydroxyacid GC/MS/MS 0,15  
205 Mebeverine acid HPLC/MS/MS 10  
206 Mebeverine acid, desmethyl HPLC/MS/MS 10  
207 Megestrol acetate HPLC/MS/MS 1  
208 Melatonin HPLC/MS/MS 0.01 in animals samples
209 Melatonin HPLC/MS/MS 0,01  
210 Meldonium HPLC/MS/MS 100  
211 Meloxicam HPLC/MS/MS 0,05  
212 Meloxicam HPLC/MS/MS 30  
213 Meloxicam HPLC/MS/MS 20  
214 Memantine HPLC/MS/MS 0,1  
215 Memantine HPLC/MS/MS 0,2  
216 Memantine HPLC/MS/MS 0,5 common method with donepezile
217 Metformin HPLC/MS/MS 10  
218 Methyldopa HPLC/MS/MS 20  
219 Methylsulfoxyethanol (MSE) HPLC/MS/MS 200  
220 Metoprolol HPLC/MS/MS 1  
221 Metronidazole HPLC/MS/MS 20  
222 Mianserin chiral HPLC/MS/MS 0,2  
223 Micophenolic acid HPLC/MS/MS 500  
224 Midazolam HPLC/MS/MS 0,2  
225 Mildronate HPLC/MS/MS 50  
226 Milnacipran HPLC/MS/MS 2  
227 Misoprostol acid HPLC/MS/MS 0,005  
228 Misoprostol acid HPLC/MS/MS 0,05  
229 Misoprostol acid HPLC/MS/MS 0,025  
230 Moclobemide HPLC 30  
231 Montelukast HPLC/MS/MS 1  
232 Montelukast HPLC/MS/MS 2 common method with levocetirizine
233 Moxifloxacin HPLC/MS/MS 50  
234 Moxonidine HPLC/MS/MS 0,02  
235 N,N-Didesmethil Sibutramine HPLC/MS/MS 0,1 common method with N-Desmethil Sibutramine and Sibutramine
236 N-Desmethil Sibutramine HPLC/MS/MS 0,1 common method with N-Didesmethyl Sibutramine and Sibutramine
237 N-Desmethil Trimebutine HPLC/MS/MS 30,0  
238 Naftidrofuryl HPLC 200  
239 Naproxen HPLC/MS/MS 200  
240 Naproxen HPLC/MS/MS 10 in urine
241 Naproxen HPLC/MS/MS 500  
242 Nebivolol HPLC/MS/MS 0,02  
243 Nerofe HPLC/MS/MS 1 000,00 in dog plasma
244 Nevirapine HPLC/MS/MS 25  
245 Nitrofurantoin HPLC/MS/MS 2  
246 Norgestimate HPLC/MS/MS 0,0004  
247 O-desmethyltramadol HPLC/MS/MS 0,5  
248 O-desmethylvenlafaxine HPLC/MS/MS 0,5  
249 O-hydroxy atorvastatin HPLC/MS/MS 0,4 common method with ezetimibe
250 Olanzapine HPLC/MS/MS 0,1  
251 Olanzapine HPLC/MS/MS 0,25  
252 Olmesartan HPLC/MS/MS 10  
253 Omeprazole HPLC/MS/MS 10  
254 Ondansetron HPLC/MS/MS 1  
255 Oracin HPLC 20  
256 Ornidazole HPLC/MS/MS 200  
257 Oseltamivir HPLC/MS/MS 0,5  
258 Oseltamivir HPLC/MS/MS 1.00  
259 Oxybutynin GC/MS 0,2  
260 Paliperidon HPLC/MS/MS 0,2  
262 Paraxantine HPLC/MS/MS 100 common method with caffeine
263 Paroxetine HPLC/MS/MS 0,1  
264 Paroxetine HPLC/MS/MS 0,025  
265 Paroxetine metabolite HPLC/MS/MS 0,2  
266 Pazopanib HPLC/MS/MS 100  
267 Pentoxifylline HPLC/MS/MS 1  
268 Pentoxifylline metabolite M1 HPLC/MS/MS 2  
269 Pentoxifylline metabolite M5 HPLC/MS/MS 10  
270 Perindopril HPLC/MS/MS 1.0 common method with perindoprilate
271 Perindopril HPLC/MS/MS 2,0  
272 Perindopril HPLC/MS/MS 2,5 common method with perindoprilate
273 Perindoprilate HPLC/MS/MS 0,25 commo method with perindopril
274 p-hydroxy atorvastatin HPLC/MS/MS 0,04 common method with ezetimibe
275 Pioglitazone HPLC/MS/MS 10  
276 Pioglitazone metabolite M IV HPLC/MS/MS 5  
277 Piracetam HPLC/MS/MS 500  
278 Pitofenone HPLC/MS/MS 1 common method with ketorolac and fenpiverinium
279 Pitofenone HPLC/MS/MS 0,002 commo method with fenpiverinium
280 Pizotifen GC/MS/MS 0,05  
281 Pramipexole HPLC/MS/MS 0,02  
282 Pramipexole HPLC/MS/MS 0,01  
283 Prednisolone HPLC/MS/MS 3  
284 Pregabalin HPLC/MS/MS 50  
285 Pridinol HPLC/MS/MS 0,2  
286 Pridinol HPLC/MS/MS 1 in urine
287 Propafenone HPLC/MS/MS 1  
288 Propiverine HPLC/MS/MS 0,5  
289 Quetiapine HPLC/MS/MS 1  
290 Quifenadine HPLC/MS/MS 0,2  
291 Raloxifene HPLC/MS/MS 0,01  
292 Raloxifene-4-glucoronide HPLC/MS/MS 1  
293 Raloxifene-6-glucoronide HPLC/MS/MS 0,5  
294 Ramipril HPLC/MS/MS 0,2  
295 Ramipril HPLC/MS/MS 0,4  
296 Ramipril HPLC/MS/MS 0,05 in dog plasma
297 Ramiprilate HPLC/MS/MS 0,2  
298 Ramiprilate HPLC/MS/MS 0,5 in dog plasma
299 Ranitidin HPLC 10  
300 Ranolazine HPLC/MS/MS 25  
302 Rasagiline HPLC/MS/MS 0,1  
303 Rebamipide HPLC/MS/MS 4  
304 Ribavirin HPLC/MS/MS 3  
305 Risperidone HPLC/MS/MS 0,1  
306 Ritonavir HPLC/MS/MS 20  
307 Rizatriptan HPLC/MS/MS 0,1  
308 Ropinirole HPLC/MS/MS 0,1  
309 Rosuvastatin HPLC/MS/MS 0,05  
310 Salicylic acid HPLC 200  
311 Salicylic acid HPLC/MS/MS 100 common method with acetylsalicylic acid
312 Salicylic acid HPLC/MS/MS 20 common method with acetylsalicylic acid
313 Sibutramine HPLC/MS/MS 0,1 common method with NN-Didesmethyl Sibutramine and N-desmethil Sibutramine
314 Sildenafil HPLC/MS/MS 1  
315 Sildenafil HPLC/MS/MS 5  
316 Simvastatin GC/MS/MS 0,5  
317 Simvastatin LC/MS/MS 0,5  
318 Simvastatin LC/MS/MS 0,2 common method with ezetimibe
319 Simvastatin LC/MS/MS 0,2  
320 Simvastatin hydroxyacid GC/MS/MS 0,1  
321 Simvastatin hydroxyacid LC/MS/MS 0,1  
322 Simvastatin hydroxyacid LC/MS/MS 0,05 common method with ezetimibe
323 Sitagliptin HPLC/MS/MS 1  
324 Solifenacin HPLC/MS/MS 0,2  
325 Sunitinibe HPLC/MS/MS 0,1  
326 Tadalafil HPLC/MS/MS 5  
327 Tamsulosin HPLC/MS/MS 0,2  
328 Tamsulosin HPLC/MS/MS 0,1  
329 Tamsulosin HPLC/MS/MS 0,05  
330 Tauroursodeoxycholic acid HPLC/MS/MS 5 endogenous compound
331 Telmisartan HPLC/MS/MS 2  
332 Tenofovir HPLC/MS/MS 5  
333 Tenofovir HPLC/MS/MS 5 common method with emtricitabine
334 Terbinafine HPLC/MS/MS 20  
335 Teriflunomide HPLC/MS/MS 100  
336 Thiamine pyrophosphate HPLC/MS/MS 5.0 in erythrocytes
337 Thiocolchicoside metabolite M1 HPLC/MS/MS 1  
338 Thiocolchicoside HPLC/MS/MS 0,01  
339 Tianeptine chiral HPLC/MS/MS 2  
340 Tilorone HPLC/MS/MS 0,75  
341 Ticagrelor HPLC/MS/MS 5  
342 Tiotropium HPLC/MS/MS 0,0001  
343

Atorvastatin

HPLC/MS/MS 0,8 common method with ezetimibe
344 Tolperisone HPLC/MS/MS 0,5  
345 Tolterodine HPLC/MS/MS 0,05  
346 Torasemide HPLC/MS/MS 20  
347 Toremifene HPLC/MS/MS 2  
348 Tramadol GC/MS 6  
349 Tramadol HPLC/MS/MS 5  
350 Trimetazidine HPLC/MS/MS 0,5  
351 Ulipristal HPLC/MS/MS 0,2  
352 Uridine HPLC/MS/MS 150 endogenous compound
353 Uridine HPLC/MS/MS 30,0  
354 Ursodeoxycholic acid HPLC/MS/MS 10 endogenous compound
355 Ursodeoxycholic acid HPLC/MS/MS 40,0 common method with tauroursodeoxycholic acid and glycodeoxycholic acid
356 Valganciclovir HPLC/MS/MS 5  
357 Valproic acid HPLC/MS/MS 250  
358 Valsartan HPLC/MS/MS 50  
359 Vardenafil HPLC/MS/MS 0,25  
360 Venlafaxine HPLC/MS/MS 10 in rat plasma
361 Venlafaxine HPLC/MS/MS 0,5  
362 Vildagliptin HPLC/MS/MS 2  
363 Vinpocetine HPLC/MS/MS 0,3  
364 Voriconazole HPLC/MS/MS 5  
365 Warfarin HPLC 20  
366 Zidovudine HPLC/MS/MS 25  
367 Zolpidem HPLC 1 plasma direct injection
368 Zopiclon HPLC 4  
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