Список валидированных методик
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№   АналитМетодLLOQ (ng/mL)Примечание
1 11-Deoxycortisol HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
2 17-Carboxybudesonide HPLC/MS/MS 0,1 in dog plasma
3 17-Deacetylnorgestimate HPLC/MS/MS 0,02  
4 17-Hydroxyprogesterone HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
5 1-Adamantylethyloxy-3-morpholino-2-propanol HPLC/MS/MS 0,05  
6 2-Hydroxymethylmetronidazole HPLC/MS/MS 4  
7 2-Pyridylacetic acid HPLC/MS/MS 200  
8 4-Methylaminoantipyrine (MAA) HPLC/MS/MS 100  
9 5'-Deoxy-5-fluorocytidine HPLC/MS/MS 25  
10 5'-Deoxy-5-fluorouridine HPLC/MS/MS 25  
11 5-Fluorouracil HPLC/MS/MS 5  
12 5-Hydroxymethyltolterodine HPLC/MS/MS 0,05  
13 5-Hydroxypropafenone HPLC/MS/MS 0,5  
14 9-Hydroxyrisperidone HPLC/MS/MS 0,1  
15 Abiraterone HPLC/MS/MS 0,2  
16 Acetaminophen (paracetamol) HPLC/MS/MS 250  
17 Acetazolamide HPLC/MS/MS 250  
18 Acetylcysteine HPLC/MS/MS 50  
19 Acetylsalicylic acid HPLC/MS/MS 25 common method with salicylic acid
20 Acetylsalicylic acid HPLC/MS/MS 5 common method with salicylic acid
21 Aciclovir HPLC 15  
22 Aciclovir HPLC/MS/MS 5  
23 Agomelatine HPLC/MS/MS 0,1  
24 Aldosterone HPLC/MS/MS 0,01 determination of endogenous levels in postmenopausal women
25 Alendronate HPLC/MS/MS 0,75  
26 Ambroxol HPLC/MS/MS 1  
27 Amlodipine HPLC/MS/MS 0,1  
28 Amlodipine HPLC/MS/MS 0,5 rat plasma direct injection
29 Amlodipine chiral HPLC/MS/MS 0,2  
30 Amoxicillin HPLC/MS/MS 100  
31 Amoxicillin HPLC/MS/MS 350 common method with Clavulanic acid
32 Amoxicillin HPLC/MS/MS 500 common method with Clavulanic acid
33 Anagrelide HPLC/MS/MS 0,075  
34 Anastrozole HPLC/MS/MS 0,5  
35 Androstenedione HPLC/MS/MS 0,02 determination of endogenous levels in postmenopausal women
36 Aripiprazene HPLC/MS/MS 0,1  
37 Aripiprazole HPLC/MS/MS 0,4  
38 Atomoxetine HPLC/MS/MS 5  
39 Atorvastatin HPLC/MS/MS 0,8 common method with ezetimibe
40 Atorvastatin HPLC/MS/MS 0,5  
41 Azithromycin HPLC/MS/MS 4  
42 Bendroflumethiazide HPLC/MS/MS 0,4  
43 Bicalutamide chiral HPLC/MS/MS 1  
44 Bicalutamide HPLC/MS/MS 2  
45 Bisoprolol HPLC/MS/MS 0,5  
46 Bosentan HPLC/MS/MS 5  
47 Bosentan HPLC/MS/MS 20  
48 Budesonide HPLC/MS/MS 0,05 in dog plasma
49 Bumetanide HPLC 4  
50 Caffeine HPLC/MS/MS 100 common method with paraxantine
51 Candesartan HPLC/MS/MS 2  
52 Capecitabine HPLC/MS/MS 100  
53 Captopril (free) HPLC/MS/MS 1  
54 Captopril (free) HPLC 15  
55 Carbamazepine HPLC 25  
56 Carbocisteine HPLC/MS/MS 50  
57 Carvedilol HPLC/MS/MS 1  
58 Carvedilol metabolite M IV HPLC/MS/MS 0,2  
59 Cefditoren HPLC/MS/MS 50  
60 Cefixime HPLC/MS/MS 100  
61 Cefprozil HPLC/MS/MS 100  
62 Cefuroxime HPLC/MS/MS 50  
63 Celecoxib HPLC/MS/MS 10  
64 Chlorambucil HPLC/MS/MS 1  
65 Chlorthalidone HPLC/MS/MS 2  
66 Cilostazol HPLC/MS/MS 50  
67 Ciprofloxacine HPLC/MS/MS 50  
68 Clarithromycin HPLC/MS/MS 50  
69 Clavulanic acid HPLC/MS/MS 80 Common method with Amoxicillin
70 Clavulanic acid HPLC/MS/MS 100 Common method with Amoxicillin
71 Clobazam HPLC/MS/MS 1  
72 Clozapin GC/MS 0,6  
73 C-peptide HPLC/MS/MS 0,2  
74 Dapagliflozin HPLC/MS/MS 2 common method with linagliptin
75 Dasatinib HPLC/MS/MS 0,25  
76 Desethyloxybutynin GC/MS 2  
77 Desethyloxybutynin HPLC 4  
78 Desloratadine HPLC/MS/MS 0,05  
79 Desmethylfluoxetine GC/MS 0,4  
80 Dexamethasone HPLC/MS/MS 0,25  
81 Dexketoprofen HPLC/MS/MS 50  
82 Diclofenac HPLC/MS/MS 5  
83 Didanosine HPLC/MS/MS 20  
84 Dienogest HPLC/MS/MS 1  
85 Diosmetin-3-O-glucuronide HPLC/MS/MS 0,05  
86 Donepezil HPLC/MS/MS 0,2  
87 Doxazosin HPLC 0,4  
88 Drospirenone HPLC/MS/MS 0,5  
89 Drotaverine HPLC/MS/MS 3  
90 Duloxetine HPLC/MS/MS 0,5  
91 Dutasteride HPLC/MS/MS 0,05  
92 Emoxipine HPLC/MS/MS 5  
93 Emtricitabine HPLC/MS/MS 5 (common with Tenofovir)
94 Emtricitabine HPLC/MS/MS 5  
95 Enalapril HPLC/MS/MS 1  
96 Enalaprilat HPLC/MS/MS 1,2  
97 Entecavir HPLC/MS/MS 0,05  
98 Eplerenon HPLC/MS/MS 10  
99 Epoxycarbamazepin HPLC 25  
100 Erlotinib HPLC/MS/MS 5  
101 Escitalopram HPLC/MS/MS 0,25  
102 Esomeprazole HPLC/MS/MS 10  
103 Estradiol HPLC/MS/MS 0,0008 determination of endogenous levels in postmenopausal women
104 Estrone HPLC/MS/MS 0,001 determination of endogenous levels in postmenopausal women
105 Estrone sulfate HPLC/MS/MS 0,01 determination of endogenous levels in postmenopausal women
106 Eszopiclon HPLC/MS/MS 0,25  
107 Ethinylestradiol HPLC/MS/MS 0,001  
108 Ethylmethylhydroxypyridine HPLC/MS/MS 0,25  
109 Ethylmethylhydroxypyridine HPLC/MS/MS 1  
110 Etoricoxib HPLC/MS/MS 5  
111 Everolimus HPLC/MS/MS 1 in whole blood
112 Exemestane HPLC/MS/MS 0,25  
113 Ezetimibe HPLC/MS/MS 0,04 common method with ezetimibe glucuronide
114 Ezetimibe HPLC/MS/MS 0,08 common method with atorvastatin
115 Ezetimibe HPLC/MS/MS 0,05 common method with simvastatin
116 Ezetimibe glucuronide HPLC/MS/MS 0,8 common method with ezetimibe
117 Ezetimibe glucuronide HPLC/MS/MS 0,8 common method with atorvastatin
118 Famotidine HPLC/MS/MS 2,5  
119 Fampridine HPLC/MS/MS 0,5  
120 Fampridine HPLC/MS/MS 1  
121 Fenpiverinium HPLC/MS/MS 0,03 common method with ketorolac and pitofenone
122 Fenpiverinium HPLC/MS/MS 0,001 common method with pitofenone
123 Fenspiride HPLC/MS/MS 1  
124 Fenspiride HPLC/MS/MS 1  
125 Fingolimod HPLC/MS/MS 0,01 in whole blood
126 Fluoxetine GC/MS 0,4  
127 Flupirtine HPLC/MS/MS 20  
128 Flupirtine HPLC/MS/MS 10  
129 Flurbiprofen HPLC/MS/MS 100  
130 Fluvoxamine HPLC 1,5  
131 Fosfomycin HPLC/MS/MS 500  
132 Ganciclovir HPLC/MS/MS 50  
133 Gefitinib HPLC/MS/MS 2  
134 Gentamicin HPLC/MS/MS   in animals samples
135 Glargine ELISA 7,5 µU/mL  
136 Gliclazide HPLC/MS/MS 20  
137 Glimepiride HPLC/MS/MS 1  
138 Glucosamine HPLC/MS/MS 10  
139 Glycoursodeoxycholic acid HPLC/MS/MS 20 endogenous compound
140 Hydrochlorothiazide HPLC/MS/MS 0,2  
141 Hydrochlorothiazide HPLC/MS/MS 0,5  
142 Hydrocortisone HPLC/MS/MS 10 endogenous compound
143 Hydroxyurea HPLC/MS/MS 250  
144 Ibuprofen HPLC/MS/MS 500  
145 Ibuprofen HPLC/MS/MS 250  
146 Ibuprofen (S, R — isomers, enantioselective) HPLC/MS/MS 250  
147 Imatinib HPLC/MS/MS 20  
148 Indapamide HPLC/MS/MS 1 in whole blood
149 Indapamide HPLC/MS/MS 0,5 in whole blood
150 Insulin ELISA 6,25 µIU/mL  
151 Insulin ELISA 12,5 µIU/mL  
152 Insulin ELISA 4 µIU/mL  
153 Insulin aspart ELISA 10 µIU/mL  
154 Ipidacrine HPLC/MS/MS 0,1  
155 Irbesartan HPLC/MS/MS 5  
156 Isoprinosine (DIP) HPLC/MS/MS 80  
157 Isoprinosine (PAcBA) HPLC/MS/MS 200  
158 Ivabradine HPLC/MS/MS 0,25  
159 Ketorolac HPLC/MS/MS 3 common method with fenpiverinium and pitofenone
160 Ketorolac HPLC/MS/MS 30  
161 Lacidipine HPLC/MS/MS 0,02  
162 Lenalidomide HPLC/MS/MS 2  
163 Letrozole HPLC/MS/MS 0,5  
164 Letrozole HPLC/MS/MS 1  
165 Levetiracetam HPLC/MS/MS 200  
166 Levocetirizine HPLC/MS/MS 2,5  
167 Levocetirizine HPLC/MS/MS 1 common method with montelucast
168 Levofloxacine HPLC/MS/MS 100  
169 Levothyroxine HPLC/MS/MS 10 endogenous compound
170 Linagliptin HPLC/MS/MS 0,1 common method with dapagliflozin
171 Linezolid HPLC/MS/MS 200  
172 Liothyronine HPLC/MS/MS 0,25 endogenous compound
173 Lisinopril HPLC/MS/MS 1  
174 Lornoxicam HPLC/MS/MS 20  
175 Losartan HPLC/MS/MS 3  
176 Lovastatin GC/MS/MS 0,15  
177 Lovastatin hydroxyacid GC/MS/MS 0,15  
178 Mebeverine acid HPLC/MS/MS 10  
179 Mebeverine acid, desmethyl HPLC/MS/MS 10  
180 Megestrol acetate HPLC/MS/MS 1  
181 Meldonium HPLC/MS/MS 100  
182 Meloxicam HPLC 30  
183 Meloxicam HPLC/MS/MS 20  
184 Memantine HPLC/MS/MS 0,2  
185 Metformin HPLC/MS/MS 10  
186 Methyldopa HPLC/MS/MS 20  
187 Methylsulfoxyethanol (MSE) HPLC/MS/MS 200  
188 Metoprolol HPLC/MS/MS 1  
189 Metronidazole HPLC/MS/MS 20  
190 Mianserin chiral HPLC/MS/MS 0,2  
191 Micophenolic acid HPLC/MS/MS 500  
192 Mildronate HPLC/MS/MS 50  
193 Milnacipran HPLC/MS/MS 2  
194 Misoprostol acid HPLC/MS/MS 0,05  
195 Misoprostol acid HPLC/MS/MS 0,025  
196 Moclobemide HPLC 30  
197 Montelukast HPLC/MS/MS 1  
198 Montelukast HPLC/MS/MS 2 common method with levocetirizine
199 Moxifloxacin HPLC/MS/MS 50  
200 Moxonidine HPLC/MS/MS 0,02  
201 Naftidrofuryl HPLC 200  
202 Naproxen HPLC/MS/MS 200  
203 Naproxen HPLC/MS/MS 10 in urine
204 Naproxen HPLC/MS/MS 500  
205 Nebivolol HPLC/MS/MS 0,02  
206 Nerofe HPLC/MS/MS 1 000,00 in dog plasma
207 Nevirapine HPLC/MS/MS 25  
208 Nitrofurantoin HPLC/MS/MS 2  
209 Norgestimate HPLC/MS/MS 0,0004  
210 O-desmethyltramadol HPLC/MS/MS 0,5  
211 O-desmethylvenlafaxine HPLC/MS/MS 0,5  
212 O-hydroxy atorvastatin HPLC/MS/MS 0,4 common method with ezetimibe
213 Olanzapine HPLC/MS/MS 0,1  
214 Olanzapine HPLC/MS/MS 0,25  
215 Olmesartan HPLC/MS/MS 10  
216 Omeprazole HPLC/MS/MS 10  
217 Ondansetron HPLC/MS/MS 1  
218 Oracin HPLC 20  
219 Ornidazole HPLC/MS/MS 200  
220 Oseltamivir HPLC/MS/MS 0,5  
221 Oxybutynin GC/MS 0,2  
222 Paliperidon HPLC/MS/MS 0,2  
223 Paraxantine HPLC/MS/MS 100 common method with caffeine
224 Paroxetine HPLC/MS/MS 0,1  
225 Paroxetine HPLC/MS/MS 0,025  
226 Paroxetine metabolite HPLC/MS/MS 0,2  
227 Pazopanib HPLC/MS/MS 100  
228 Pentoxifylline HPLC/MS/MS 1  
229 Pentoxifylline metabolite M1 HPLC/MS/MS 2  
230 Pentoxifylline metabolite M5 HPLC/MS/MS 10  
231 p-hydroxy atorvastatin HPLC/MS/MS 0,04 common method with ezetimibe
232 Pioglitazone HPLC/MS/MS 10  
233 Pioglitazone metabolite M IV HPLC/MS/MS 5  
234 Piracetam HPLC/MS/MS 500  
235 Pitofenone HPLC/MS/MS 1 common method with ketorolac and fenpiverinium
236 Pitofenone HPLC/MS/MS 0,002 commo method with fenpiverinium
237 Pizotifen GC/MS/MS 0,05  
238 Pramipexole HPLC/MS/MS 0,02  
239 Pramipexole HPLC/MS/MS 0,01  
240 Prednisolone HPLC/MS/MS 3  
241 Pregabalin HPLC/MS/MS 50  
242 Pridinol HPLC/MS/MS 0,2  
243 Pridinol HPLC/MS/MS 1 in urine
244 Propafenone HPLC/MS/MS 1  
245 Propiverine HPLC/MS/MS 0,5  
246 Quetiapine HPLC/MS/MS 1  
247 Raloxifene HPLC/MS/MS 0,01  
248 Raloxifene-4-glucoronide HPLC/MS/MS 1  
249 Raloxifene-6-glucoronide HPLC/MS/MS 0,5  
250 Ramipril HPLC/MS/MS 0,2  
251 Ramipril HPLC/MS/MS 0,4  
252 Ramipril HPLC/MS/MS 0,05 in dog plasma
253 Ramiprilate HPLC/MS/MS 0,2  
254 Ramiprilate HPLC/MS/MS 0,5 in dog plasma
255 Ranitidin HPLC 10  
256 Ranolazine HPLC/MS/MS 25  
257 Rasagiline HPLC/MS/MS 0,1  
258 Rebamipide HPLC/MS/MS 4  
259 Ribavirin HPLC/MS/MS 3  
260 Risperidone HPLC/MS/MS 0,1  
261 Ritonavir HPLC/MS/MS 20  
262 Rizatriptan HPLC/MS/MS 0,1  
263 Ropinirole HPLC/MS/MS 0,1  
264 Rosuvastatin HPLC/MS/MS 0,05  
265 Salicylic acid HPLC 200  
266 Salicylic acid HPLC/MS/MS 100 common method with acetylsalicylic acid
267 Salicylic acid HPLC/MS/MS 20 common method with acetylsalicylic acid
268 Sildenafil HPLC/MS/MS 1  
269 Sildenafil HPLC/MS/MS 5  
270 Simvastatin GC/MS/MS 0,5  
271 Simvastatin LC/MS/MS 0,5  
272 Simvastatin LC/MS/MS 0,2 common method with ezetimibe
273 Simvastatin LC/MS/MS 0,2  
274 Simvastatin hydroxyacid GC/MS/MS 0,1  
275 Simvastatin hydroxyacid LC/MS/MS 0,1  
276 Simvastatin hydroxyacid LC/MS/MS 0,05 common method with ezetimibe
277 Sitagliptin HPLC/MS/MS 1  
278 Solifenacin HPLC/MS/MS 0,2  
279 Tadalafil HPLC/MS/MS 5  
280 Tamsulosin HPLC/MS/MS 0,2  
281 Tamsulosin HPLC/MS/MS 0,1  
282 Tamsulosin HPLC/MS/MS 0,05  
283 Tauroursodeoxycholic acid HPLC/MS/MS 5 endogenous compound
284 Telmisartan HPLC/MS/MS 2  
285 Tenofovir HPLC/MS/MS 5  
286 Tenofovir HPLC/MS/MS 5 common method with emtricitabine
287 Terbinafine HPLC/MS/MS 20  
288 Teriflunomide HPLC/MS/MS 100  
289 Thiocolchicoside metabolite M1 HPLC/MS/MS 1  
290 Tianeptine chiral HPLC/MS/MS 2  
291 Tilorone HPLC/MS/MS 0,75  
292 Ticagrelor HPLC/MS/MS 5  
293 Tolperisone HPLC/MS/MS 0,5  
294 Tolterodine HPLC/MS/MS 0,05  
295 Torasemide HPLC/MS/MS 20  
296 Toremifene HPLC/MS/MS 2  
297 Tramadol GC/MS 6  
298 Tramadol HPLC/MS/MS 5  
299 Trimetazidine HPLC/MS/MS 0,5  
300 Ulipristal HPLC/MS/MS 0,2  
301 Uridine HPLC/MS/MS 150 endogenous compound
302 Ursodeoxycholic acid HPLC/MS/MS 10 endogenous compound
303 Valganciclovir HPLC/MS/MS 5  
304 Valproic acid HPLC/MS/MS 250  
305 Valsartan HPLC/MS/MS 50  
306 Vardenafil HPLC/MS/MS 0,25  
307 Venlafaxine HPLC/MS/MS 10 in rat plasma
308 Venlafaxine HPLC/MS/MS 0,5  
309 Vinpocetine HPLC/MS/MS 0,3  
310 Voriconazole HPLC/MS/MS 5  
311 Warfarin HPLC 20  
312 Zidovudine HPLC/MS/MS 25  
313 Zolpidem HPLC 1 plasma direct injection
314 Zopiclon HPLC 4  
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